Evaluation of hepatitis C virus glycoprotein E2 for vaccine design: an endoplasmic reticulum-retained recombinant protein is superior to secreted recombinant protein and DNA-based vaccine candidates.

Heile, J M; Fong, Y L; Rosa, D; Berger, K; Saletti, G; Campagnoli, S; Bensi, G; Capo, S; Coates, S; Crawford, K; Dong, C; Wininger, M; Baker, G; Cousens, L; Chien, D; Ng, P; Archangel, P; Grandi, G; Houghton, M; Abrignani, S

Heile, J M; Fong, Y L; Rosa, D; Berger, K; Saletti, G; Campagnoli, S; Bensi, G; Capo, S; Coates, S; Crawford, K; Dong, C; Wininger, M; Baker, G; Cousens, L; Chien, D; Ng, P; Archangel, P; Grandi, G; Houghton, M; Abrignani, S.

Affiliation

Heile JM; IRIS Research Center, Chiron, 53100 Siena, Italy.

J Virol ; 74(15): 6885-92, 2000 Aug.

Article in En | MEDLINE | ID: mdl-10888628

Subject(s)

Hepacivirus/immunology; Hepatitis C/prevention & control; Membrane Proteins; Vaccines, DNA/immunology; Viral Envelope Proteins/genetics; Viral Envelope Proteins/immunology; Viral Hepatitis Vaccines/immunology; Animals; Antigens, CD/metabolism; Drug Design; Endoplasmic Reticulum/metabolism; Evaluation Studies as Topic; Female; Glycosylation; Guinea Pigs; Hepatitis C Antibodies/blood; Humans; Immunization; Mice; Mice, Inbred C57BL; Recombinant Proteins/immunology; Recombinant Proteins/metabolism; Tetraspanin 28; Viral Envelope Proteins/chemistry; Viral Envelope Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Hepatitis Vaccines / Viral Envelope Proteins / Hepatitis C / Hepacivirus / Vaccines, DNA / Membrane Proteins Type of study: Diagnostic_studies / Evaluation_studies Limits: Animals / Female / Humans Language: En Journal: J Virol Year: 2000 Document type: Article Affiliation country: Italy

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