Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.

Seiffert, D; Bradley, J D; Rominger, C M; Rominger, D H; Yang, F; Meredith, J E; Wang, Q; Roach, A H; Thompson, L A; Spitz, S M; Higaki, J N; Prakash, S R; Combs, A P; Copeland, R A; Arneric, S P; Hartig, P R; Robertson, D W; Cordell, B; Stern, A M; Olson, R E; Zaczek, R

Seiffert, D; Bradley, J D; Rominger, C M; Rominger, D H; Yang, F; Meredith, J E; Wang, Q; Roach, A H; Thompson, L A; Spitz, S M; Higaki, J N; Prakash, S R; Combs, A P; Copeland, R A; Arneric, S P; Hartig, P R; Robertson, D W; Cordell, B; Stern, A M; Olson, R E; Zaczek, R.

Affiliation

Seiffert D; DuPont Pharmaceuticals Company, Wilmington, Delaware 19880, USA. Dietmar.A.Seiffert@DuPontpharma.com

J Biol Chem ; 275(44): 34086-91, 2000 Nov 03.

Article in En | MEDLINE | ID: mdl-10915801

Subject(s)

Endopeptidases/drug effects; Enzyme Inhibitors/metabolism; Membrane Proteins/metabolism; Amyloid Precursor Protein Secretases; Cell Membrane/metabolism; Endopeptidases/metabolism; Precipitin Tests; Presenilin-1; Presenilin-2; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Enzyme Inhibitors / Membrane Proteins Language: En Journal: J Biol Chem Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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