Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.

Natsume, T; Watanabe, J; Tamaoki, S; Fujio, N; Miyasaka, K; Kobayashi, M

Natsume, T; Watanabe, J; Tamaoki, S; Fujio, N; Miyasaka, K; Kobayashi, M.

Affiliation

Natsume T; Teikoku Hormone Mfg. Co., Ltd., Takatsu-ku, Kawasaki, Kanagawa 213-8522, Japan.

Jpn J Cancer Res ; 91(7): 737-47, 2000 Jul.

Article in En | MEDLINE | ID: mdl-10920282

Subject(s)

Antineoplastic Agents/pharmacology; Microtubules/drug effects; Oligopeptides/pharmacology; Tubulin Modulators; Tubulin/metabolism; Animals; Antineoplastic Agents, Phytogenic/antagonists & inhibitors; Antineoplastic Agents, Phytogenic/metabolism; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Binding, Competitive; Cattle; Depsipeptides; Drug Interactions; Guanosine Triphosphate/antagonists & inhibitors; Guanosine Triphosphate/metabolism; Guanosine Triphosphate/pharmacology; Hydrolysis/drug effects; Kinetics; Microtubules/metabolism; Oligopeptides/administration & dosage; Paclitaxel/administration & dosage; Paclitaxel/pharmacology; Swine; Vinblastine/antagonists & inhibitors; Vinblastine/metabolism; Vinblastine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Tubulin / Tubulin Modulators / Microtubules / Antineoplastic Agents Limits: Animals Language: En Journal: Jpn J Cancer Res Journal subject: NEOPLASIAS Year: 2000 Document type: Article Affiliation country: Japan Country of publication: Japan

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