The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease.

Bordeaux, M C; Forcet, C; Granger, L; Corset, V; Bidaud, C; Billaud, M; Bredesen, D E; Edery, P; Mehlen, P

Bordeaux, M C; Forcet, C; Granger, L; Corset, V; Bidaud, C; Billaud, M; Bredesen, D E; Edery, P; Mehlen, P.

Affiliation

Bordeaux MC; Laboratoire Apoptose et Différenciation, label La Ligue contre le Cancer et Laboratoire de Génétique Humaine - Centre de Génétique Moléculaire et Cellulaire, CNRS UMR 5534, Université Lyon 1, 69622 Villeurbanne, France.

EMBO J ; 19(15): 4056-63, 2000 Aug 01.

Article in En | MEDLINE | ID: mdl-10921886

Subject(s)

Apoptosis; Drosophila Proteins; Hirschsprung Disease/etiology; Nerve Growth Factors; Proto-Oncogene Proteins/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Autonomic Nervous System Diseases/etiology; Caspases/metabolism; Enteric Nervous System/pathology; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hirschsprung Disease/genetics; Ligands; Nerve Tissue Proteins/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases/genetics; Recombinant Proteins/metabolism; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Apoptosis / Receptor Protein-Tyrosine Kinases / Drosophila Proteins / Hirschsprung Disease / Nerve Growth Factors Type of study: Etiology_studies Language: En Journal: EMBO J Year: 2000 Document type: Article Affiliation country: France Country of publication: United kingdom

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