Development of streptococcal pyrogenic exotoxin C vaccine toxoids that are protective in the rabbit model of toxic shock syndrome.

McCormick, J K; Tripp, T J; Olmsted, S B; Matsuka, Y V; Gahr, P J; Ohlendorf, D H; Schlievert, P M

McCormick, J K; Tripp, T J; Olmsted, S B; Matsuka, Y V; Gahr, P J; Ohlendorf, D H; Schlievert, P M.

Affiliation

McCormick JK; Departments ofMicrobiology and Biochemistry, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

J Immunol ; 165(4): 2306-12, 2000 Aug 15.

Article in En | MEDLINE | ID: mdl-10925320

Subject(s)

Bacterial Proteins; Bacterial Vaccines/immunology; Exotoxins/immunology; Membrane Proteins; Pyrogens/immunology; Shock, Septic/immunology; Shock, Septic/prevention & control; Streptococcus pyogenes/immunology; Toxoids/immunology; Animals; Bacterial Vaccines/administration & dosage; Bacterial Vaccines/chemical synthesis; Bacterial Vaccines/genetics; Cells, Cultured; Dimerization; Disease Models, Animal; Exotoxins/administration & dosage; Exotoxins/chemical synthesis; Exotoxins/genetics; Humans; Infusion Pumps, Implantable; Lymphocyte Activation; Models, Molecular; Mutagenesis, Site-Directed; Pyrogens/administration & dosage; Pyrogens/chemical synthesis; Pyrogens/genetics; Rabbits; Streptococcus pyogenes/genetics; Structure-Activity Relationship; Toxoids/administration & dosage; Toxoids/chemical synthesis; Toxoids/genetics; Vaccines, Synthetic/chemistry; Vaccines, Synthetic/genetics; Vaccines, Synthetic/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrogens / Shock, Septic / Streptococcus pyogenes / Bacterial Proteins / Toxoids / Bacterial Vaccines / Exotoxins / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2000 Document type: Article Affiliation country: United States

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