Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs.

Yew, N S; Zhao, H; Wu, I H; Song, A; Tousignant, J D; Przybylska, M; Cheng, S H

Yew, N S; Zhao, H; Wu, I H; Song, A; Tousignant, J D; Przybylska, M; Cheng, S H.

Affiliation

Yew NS; Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA. nelson.yew@genzyme.com

Mol Ther ; 1(3): 255-62, 2000 Mar.

Article in En | MEDLINE | ID: mdl-10933941

Subject(s)

CpG Islands; DNA, Bacterial/immunology; Gene Transfer Techniques; Administration, Intranasal; Animals; Antimalarials/immunology; Antimalarials/pharmacology; Bronchoalveolar Lavage Fluid/immunology; Chloroquine/immunology; Chloroquine/pharmacology; Cytokines/antagonists & inhibitors; Cytokines/biosynthesis; DNA, Bacterial/genetics; Genetic Vectors/genetics; Genetic Vectors/immunology; Inflammation/immunology; Interleukin-12/antagonists & inhibitors; Interleukin-12/biosynthesis; Lipids; Lung/metabolism; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Plasmids; Quinacrine/immunology; Quinacrine/pharmacology; Sequence Deletion; Spleen/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: DNA, Bacterial / Gene Transfer Techniques / CpG Islands Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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