Polyglutamation of antifolates is not required for induction of extracellular release of adenosine or expression of their anti-inflammatory effects.

Urakawa, K; Mihara, M; Suzuki, T; Kawamura, A; Akamatsu, K; Takeda, Y; Kamatani, N

Urakawa, K; Mihara, M; Suzuki, T; Kawamura, A; Akamatsu, K; Takeda, Y; Kamatani, N.

Affiliation

Urakawa K; Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Shizuoka 412-8513, Gotemba, Japan. urakawakzm@chugai-pharm.co.jp

Immunopharmacology ; 48(2): 137-44, 2000 Jul 20.

Article in En | MEDLINE | ID: mdl-10936511

Subject(s)

2-Aminoadipic Acid/analogs & derivatives; Adenosine/metabolism; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Extracellular Space/immunology; Extracellular Space/metabolism; Folic Acid Antagonists/metabolism; Methotrexate/analogs & derivatives; Methotrexate/metabolism; Pteroylpolyglutamic Acids/metabolism; 2-Aminoadipic Acid/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/metabolism; Cattle; Cell Line; Extracellular Space/drug effects; Female; Folic Acid Antagonists/pharmacology; Humans; Methotrexate/pharmacology; Mice; Mice, Inbred BALB C

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Collection: 01-internacional Database: MEDLINE Main subject: Adenosine / Pteroylpolyglutamic Acids / Anti-Inflammatory Agents, Non-Steroidal / Methotrexate / Extracellular Space / Folic Acid Antagonists / 2-Aminoadipic Acid Limits: Animals / Female / Humans Language: En Journal: Immunopharmacology Year: 2000 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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