Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line.
Am J Physiol Endocrinol Metab
; 279(3): E654-62, 2000 Sep.
Article
in En
| MEDLINE
| ID: mdl-10950835
ABSTRACT
Acute parathyroid hormone exposure induces vascular smooth muscle relaxation. In contrast, continuous infusion of parathyroid hormone leads to vasoconstriction and an elevation of blood pressure. Despite the known effects of parathyroid hormone on vascular smooth muscle, possible direct effects on the vascular endothelium have not previously been investigated. Using a human umbilical vein endothelial cell line, we found that parathyroid hormone increased both intracellular calcium and cellular cAMP content in these endothelial cells. Furthermore, exposure of these cells to increasing concentrations of parathyroid hormone stimulated both [(3)H]thymidine incorporation and endothelin-1 secretion. Parathyroid hormone/parathyroid hormone-related peptide receptor mRNA could be detected at low levels in these cells. In summary, these data demonstrate that endothelium-derived cells contain functional parathyroid hormone receptors. The potential physiological role of these receptors remains to be determined.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Umbilical Veins
/
Endothelium, Vascular
/
Receptors, Parathyroid Hormone
Limits:
Humans
Language:
En
Journal:
Am J Physiol Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Year:
2000
Document type:
Article
Affiliation country:
United States