Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine.

Ngui, J S; Tang, W; Stearns, R A; Shou, M; Miller, R R; Zhang, Y; Lin, J H; Baillie, T A

Ngui, J S; Tang, W; Stearns, R A; Shou, M; Miller, R R; Zhang, Y; Lin, J H; Baillie, T A.

Affiliation

Ngui JS; Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065, USA.

Drug Metab Dispos ; 28(9): 1043-50, 2000 Sep.

Article in En | MEDLINE | ID: mdl-10950847

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Diclofenac/pharmacokinetics; Mixed Function Oxygenases/metabolism; Quinidine/pharmacokinetics; Cytochrome P-450 CYP3A; Cytochrome c Group/metabolism; Diclofenac/analogs & derivatives; Diclofenac/metabolism; Diclofenac/pharmacology; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver/cytology; Liver/drug effects; Liver/metabolism; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Oxidation-Reduction; Oxidoreductases/metabolism; Quinidine/pharmacology; Recombinant Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Quinidine / Diclofenac / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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