Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies.

Tree, T I; Morgenthaler, N G; Duhindan, N; Hicks, K E; Madec, A M; Scherbaum, W A; Banga, J P

Tree, T I; Morgenthaler, N G; Duhindan, N; Hicks, K E; Madec, A M; Scherbaum, W A; Banga, J P.

Affiliation

Tree TI; Guy's, King's, St Thomas' School of Medicine, Division of Medicine, London, UK.

Diabetologia ; 43(7): 881-9, 2000 Jul.

Article in En | MEDLINE | ID: mdl-10952461

Subject(s)

Autoantibodies/blood; Diabetes Mellitus, Type 2/immunology; Glutamate Decarboxylase/chemistry; Glutamate Decarboxylase/immunology; Isoenzymes/chemistry; Isoenzymes/immunology; Amino Acid Sequence; Amino Acid Substitution; Antibodies, Monoclonal/chemistry; Autoantibodies/chemistry; Base Sequence; Binding Sites, Antibody; DNA Primers; Diabetes Mellitus, Type 2/blood; Glutamate Decarboxylase/genetics; Humans; Immunoglobulin G/blood; Immunoglobulin G/chemistry; Isoenzymes/genetics; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Recombinant Proteins/chemistry; Recombinant Proteins/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Diabetes Mellitus, Type 2 / Glutamate Decarboxylase / Isoenzymes Limits: Humans Language: En Journal: Diabetologia Year: 2000 Document type: Article Affiliation country: United kingdom Country of publication: Germany

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