A monoclonal IgG4 (lambda) with factor V inhibitory activity.
J Immunol
; 122(5): 2119-21, 1979 May.
Article
in En
| MEDLINE
| ID: mdl-109525
ABSTRACT
A monoclonal IgG4 (lambda) with inhibitory activity to human coagulation factor V was isolated from the serum of a patient with a fatal hemorrhagic diathesis by using a combination of DE-52 ion exchange chromatography and isoelectric focusing techniques. Using the criteria for defining a monoclonal immunoglobulin of restricted mobility on protein electrophoresis, immunoelectrophoresis, and isoelectric focusing, as well as neutralization with class, subclass, and light chain type antisera, we are the first to demonstrate a factor V inhibitor as a monoclonal IgG4 (lambda) detectable in serum or plasma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Factor V
/
Immunoglobulin G
Limits:
Humans
Language:
En
Journal:
J Immunol
Year:
1979
Document type:
Article