Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome.

Abriel, H; Wehrens, X H; Benhorin, J; Kerem, B; Kass, R S

Abriel, H; Wehrens, X H; Benhorin, J; Kerem, B; Kass, R S.

Affiliation

Abriel H; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

Circulation ; 102(8): 921-5, 2000 Aug 22.

Article in En | MEDLINE | ID: mdl-10952963

Subject(s)

Anti-Arrhythmia Agents/pharmacology; Long QT Syndrome/genetics; Sodium Channel Blockers; Sodium Channels/genetics; Cell Line; Dose-Response Relationship, Drug; Flecainide/pharmacology; Genetic Linkage; Humans; Kinetics; Lidocaine/pharmacology; Long QT Syndrome/drug therapy; Membrane Potentials/drug effects; Membrane Potentials/physiology; NAV1.5 Voltage-Gated Sodium Channel; Point Mutation; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome / Sodium Channels / Sodium Channel Blockers / Anti-Arrhythmia Agents Limits: Humans Language: En Journal: Circulation Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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