3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.

Bebbington, D; Monck, N J; Gaur, S; Palmer, A M; Benwell, K; Harvey, V; Malcolm, C S; Porter, R H

Bebbington, D; Monck, N J; Gaur, S; Palmer, A M; Benwell, K; Harvey, V; Malcolm, C S; Porter, R H.

Affiliation

Bebbington D; Department of Chemistry, Cerebrus, Winnersh, Wokingham, UK. david_bebbington@vpharm.com

J Med Chem ; 43(15): 2779-82, 2000 Jul 27.

Article in En | MEDLINE | ID: mdl-10956184

Subject(s)

Antioxidants/chemical synthesis; Free Radical Scavengers/chemical synthesis; Lipid Peroxidation/drug effects; Neuroprotective Agents/chemical synthesis; Oxidative Stress/drug effects; Pyridones/chemical synthesis; Animals; Antioxidants/chemistry; Antioxidants/pharmacology; Brain/cytology; Brain/drug effects; Brain/metabolism; Drug Evaluation, Preclinical; Free Radical Scavengers/chemistry; Free Radical Scavengers/pharmacology; In Vitro Techniques; Iodoacetates; Neuroprotective Agents/chemistry; Neuroprotective Agents/pharmacology; Pyridones/chemistry; Pyridones/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Lipid Peroxidation / Free Radical Scavengers / Oxidative Stress / Neuroprotective Agents / Antioxidants Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2000 Document type: Article Affiliation country: United kingdom Country of publication: United States

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