Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein.

Xu, X; Clarke, P; Szalai, G; Shively, J E; Williams, L E; Shyr, Y; Shi, E; Primus, F J

Xu, X; Clarke, P; Szalai, G; Shively, J E; Williams, L E; Shyr, Y; Shi, E; Primus, F J.

Affiliation

Xu X; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Cancer Res ; 60(16): 4475-84, 2000 Aug 15.

Article in En | MEDLINE | ID: mdl-10969795

Subject(s)

Carcinoembryonic Antigen/immunology; Immunoglobulin Fragments/immunology; Immunotoxins/pharmacology; Interleukin-2/pharmacology; Recombinant Fusion Proteins/pharmacology; Animals; Carcinoembryonic Antigen/metabolism; Colonic Neoplasms/drug therapy; Colonic Neoplasms/immunology; Colonic Neoplasms/metabolism; Drug Stability; Female; Genetic Engineering; Immunoglobulin Fragments/genetics; Immunoglobulin Fragments/metabolism; Immunotoxins/genetics; Immunotoxins/pharmacokinetics; Interleukin-2/pharmacokinetics; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Transplantation; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/pharmacokinetics; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunoglobulin Fragments / Carcinoembryonic Antigen / Immunotoxins / Interleukin-2 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Res Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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