Significance of chemokines and activated platelets in patients with diabetes.
Clin Exp Immunol
; 121(3): 437-43, 2000 Sep.
Article
in En
| MEDLINE
| ID: mdl-10971508
ABSTRACT
Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (pltP-selectin or pltannexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on activation normally T-cell expressed and secreted (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from diabetic and control patients in order to develop a better understanding of their potential contribution to diabetic vascular complications. Significant increases were found for PMPs, pltP-selectin, MCP-1, RANTES and soluble P- and E-selectins in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after ticlopidine treatment, most of these factors receded to baseline levels observed in non-diabetic patients. Our findings indicate that ticlopidine might be able to prevent or reduce vascular complications in diabetic patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platelet Activation
/
Chemokines
/
Diabetes Mellitus, Type 2
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Exp Immunol
Year:
2000
Document type:
Article
Affiliation country:
Japan