The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes.

Kawaguchi, A; Ohmori, M; Harada, K; Tsuruoka, S; Sugimoto, K; Fujimura, A

Kawaguchi, A; Ohmori, M; Harada, K; Tsuruoka, S; Sugimoto, K; Fujimura, A.

Affiliation

Kawaguchi A; Department of Clinical Pharmacology, Jichi Medical School, 3311-1 Minamikawachi-machi, Kawachi-gun, 329-0498, Tochigi, Japan.

Eur J Pharmacol ; 403(3): 203-8, 2000 Sep 08.

Article in En | MEDLINE | ID: mdl-10973620

Subject(s)

Amides/pharmacology; Enzyme Inhibitors/pharmacology; Neutrophils/metabolism; Protein Serine-Threonine Kinases/antagonists & inhibitors; Pyridines/pharmacology; Superoxides/metabolism; Adult; Calcimycin/pharmacology; Calcium/metabolism; Cell Adhesion/drug effects; Cell Aggregation/drug effects; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Humans; In Vitro Techniques; Indicators and Reagents; Intracellular Signaling Peptides and Proteins; N-Formylmethionine Leucyl-Phenylalanine/pharmacology; Neutrophils/drug effects; Oxygen Consumption/drug effects; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/physiology; Tetradecanoylphorbol Acetate/pharmacology; Thapsigargin/pharmacology; rho-Associated Kinases

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Protein Serine-Threonine Kinases / Superoxides / Enzyme Inhibitors / Amides / Neutrophils Limits: Adult / Humans Language: En Journal: Eur J Pharmacol Year: 2000 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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