Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency.

Christiansen-Weber, T A; Voland, J R; Wu, Y; Ngo, K; Roland, B L; Nguyen, S; Peterson, P A; Fung-Leung, W P

Christiansen-Weber, T A; Voland, J R; Wu, Y; Ngo, K; Roland, B L; Nguyen, S; Peterson, P A; Fung-Leung, W P.

Affiliation

Christiansen-Weber TA; R. W. Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA.

Am J Pathol ; 157(3): 1017-29, 2000 Sep.

Article in En | MEDLINE | ID: mdl-10980140

Subject(s)

ATP-Binding Cassette Transporters/physiology; Cholesterol, HDL/deficiency; Disease Models, Animal; Glomerulonephritis/etiology; Placenta/abnormalities; Tangier Disease/etiology; ATP Binding Cassette Transporter 1; Animals; Animals, Newborn; Blotting, Northern; Blotting, Southern; Cholesterol, HDL/blood; DNA/analysis; DNA Mutational Analysis; DNA Primers/chemistry; Female; Fetal Death; Glomerulonephritis/metabolism; Glomerulonephritis/pathology; In Situ Hybridization; Male; Mice; Mice, Knockout; Mutation; Placenta/metabolism; Placenta/pathology; Polymerase Chain Reaction; Pregnancy; RNA, Messenger/metabolism; Tangier Disease/metabolism; Tangier Disease/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placenta / Tangier Disease / ATP-Binding Cassette Transporters / Disease Models, Animal / Glomerulonephritis / Cholesterol, HDL Type of study: Etiology_studies Limits: Animals / Pregnancy Language: En Journal: Am J Pathol Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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