Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.

Rusyn, I; Yamashina, S; Segal, B H; Schoonhoven, R; Holland, S M; Cattley, R C; Swenberg, J A; Thurman, R G

Rusyn, I; Yamashina, S; Segal, B H; Schoonhoven, R; Holland, S M; Cattley, R C; Swenberg, J A; Thurman, R G.

Affiliation

Rusyn I; Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, USA.

Cancer Res ; 60(17): 4798-803, 2000 Sep 01.

Article in En | MEDLINE | ID: mdl-10987289

Subject(s)

Carcinogens/toxicity; Liver/drug effects; NADPH Oxidases/metabolism; Peroxisome Proliferators/toxicity; Pyrimidines/toxicity; Superoxides/toxicity; Animals; Cell Division/drug effects; Enzyme Inhibitors/pharmacology; Female; Kupffer Cells/cytology; Kupffer Cells/drug effects; Kupffer Cells/enzymology; Liver/cytology; Liver/enzymology; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases/antagonists & inhibitors; NF-kappa B/physiology; Onium Compounds/pharmacology; Phosphoproteins/deficiency; Phosphoproteins/genetics; Phosphoproteins/metabolism; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Rats; Rats, Sprague-Dawley; Superoxides/antagonists & inhibitors; Superoxides/metabolism; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/genetics

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Carcinogens / Superoxides / NADPH Oxidases / Peroxisome Proliferators / Liver Limits: Animals Language: En Journal: Cancer Res Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links