Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.
Eur J Pharmacol
; 400(2-3): 195-8, 2000 Jul 21.
Article
in En
| MEDLINE
| ID: mdl-10988333
ABSTRACT
Multidrug resistance protein 2 (MRP2) is an ATP-dependent transporter of anionic drugs and conjugates. It functions as an efflux pump in the apical membranes of liver and kidney cells, but its membrane localization in small intestine has not yet been defined. The present study demonstrates exclusive localization of Mrp2 to the brush-border (apical) membrane of villi, decreasing in intensity from the villus tip to the crypts. In immunoblot analysis of crude membranes of various rabbit tissues, Mrp2 was only found in small intestine, kidney and liver. These results are in-line with the supposed function of Mrp2 in drug excretion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Intestine, Small
Limits:
Animals
Language:
En
Journal:
Eur J Pharmacol
Year:
2000
Document type:
Article
Affiliation country:
Netherlands