Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Yu, G; Nishimura, M; Arawaka, S; Levitan, D; Zhang, L; Tandon, A; Song, Y Q; Rogaeva, E; Chen, F; Kawarai, T; Supala, A; Levesque, L; Yu, H; Yang, D S; Holmes, E; Milman, P; Liang, Y; Zhang, D M; Xu, D H; Sato, C; Rogaev, E; Smith, M; Janus, C; Zhang, Y; Aebersold, R; Farrer, L S; Sorbi, S; Bruni, A; Fraser, P; St George-Hyslop, P

Yu, G; Nishimura, M; Arawaka, S; Levitan, D; Zhang, L; Tandon, A; Song, Y Q; Rogaeva, E; Chen, F; Kawarai, T; Supala, A; Levesque, L; Yu, H; Yang, D S; Holmes, E; Milman, P; Liang, Y; Zhang, D M; Xu, D H; Sato, C; Rogaev, E; Smith, M; Janus, C; Zhang, Y; Aebersold, R; Farrer, L S; Sorbi, S; Bruni, A; Fraser, P; St George-Hyslop, P.

Affiliation

Yu G; Centre for Research in Neurodegenerative Diseases, Toronto Western Hospital, and Department of Medicine (Neurology), University of Toronto, Ontario, Canada.

Nature ; 407(6800): 48-54, 2000 Sep 07.

Article in En | MEDLINE | ID: mdl-10993067

Subject(s)

Amyloid beta-Protein Precursor/metabolism; Caenorhabditis elegans Proteins; Membrane Glycoproteins/metabolism; Membrane Glycoproteins/physiology; Membrane Proteins/metabolism; Signal Transduction; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Caenorhabditis elegans; DNA, Complementary; Endopeptidases/metabolism; Humans; Membrane Glycoproteins/genetics; Molecular Sequence Data; Presenilin-1; Presenilin-2; Receptors, Notch; Sequence Homology, Amino Acid; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Signal Transduction / Amyloid beta-Protein Precursor / Caenorhabditis elegans Proteins / Membrane Proteins Limits: Animals / Humans Language: En Journal: Nature Year: 2000 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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