Serotonergic retinopetal projections from the dorsal raphe nucleus in the mouse demonstrated by combined [(3)H] 5-HT retrograde tracing and immunolabeling of endogenous 5-HT.
Brain Res
; 878(1-2): 213-7, 2000 Sep 29.
Article
in En
| MEDLINE
| ID: mdl-10996155
ABSTRACT
The present study demonstrated a direct serotonergic retinopetal projection in the mouse stemming from the lateral portion of the dorsal raphe nucleus bilaterally. A double-labeling technique was employed combining (1) radioautography and retrograde axonal tracing following intraocular injection of [(3)H] 5-HT and (2) immunocytochemical identification of endogenous 5-HT. Radiolabeled neurons were only observed within the dorsal raphe nucleus and were always double-labeled with the 5-HT antibody. The radiolabeling appeared to be specific resulting from the retrograde transport of a radioactive 5-HT derivative product following uptake of the neurotransmitter by intraretinal terminals.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Raphe Nuclei
/
Serotonin
/
Synaptic Transmission
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
2000
Document type:
Article
Affiliation country:
France