Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia.

Ikeda, K; Kobayashi, T; Kumanishi, T; Niki, H; Yano, R

Ikeda, K; Kobayashi, T; Kumanishi, T; Niki, H; Yano, R.

Affiliation

Ikeda K; Laboratory for Neurobiology of Emotion, RIKEN, Brain Science Institute, Wako, Saitama, Japan. ikedak@postman.riken.go.jp

Neurosci Res ; 38(1): 113-6, 2000 Sep.

Article in En | MEDLINE | ID: mdl-10997585

Subject(s)

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology; Analgesia; Morphine/pharmacology; Pain Measurement/drug effects; Potassium Channels, Inwardly Rectifying; Potassium Channels/metabolism; Analgesics, Non-Narcotic/pharmacology; Analgesics, Opioid/pharmacology; Animals; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; Potassium Channels/deficiency; Potassium Channels/genetics; Reaction Time/drug effects; Receptors, Opioid, kappa/agonists; Receptors, Opioid, kappa/metabolism; Receptors, Opioid, mu/agonists; Receptors, Opioid, mu/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pain Measurement / Potassium Channels / 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / Potassium Channels, Inwardly Rectifying / Analgesia / Morphine Limits: Animals Language: En Journal: Neurosci Res Journal subject: NEUROLOGIA Year: 2000 Document type: Article Affiliation country: Japan Country of publication: Ireland

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