Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT.

Sagnou, M J; Howard, P W; Gregson, S J; Eno-Amooquaye, E; Burke, P J; Thurston, D E

Sagnou, M J; Howard, P W; Gregson, S J; Eno-Amooquaye, E; Burke, P J; Thurston, D E.

Affiliation

Sagnou MJ; CRC Gene Targeting Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hants, UK.

Bioorg Med Chem Lett ; 10(18): 2083-6, 2000 Sep 18.

Article in En | MEDLINE | ID: mdl-10999476

Subject(s)

Benzodiazepines/chemical synthesis; Benzodiazepines/pharmacology; Pyrroles/chemical synthesis; Pyrroles/pharmacology; Antibiotics, Antineoplastic/chemical synthesis; Antibiotics, Antineoplastic/pharmacology; Cell Death/drug effects; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; NAD/pharmacology; Nitroreductases/pharmacology; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Benzodiazepines Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2000 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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