Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.

Chan, W N; Hadley, M S; Harling, J D; Herdon, H J; Orlek, B S; Riley, G J; Stead, R E; Stean, T O; Thompson, M; Upton, N; Ward, R W

Chan, W N; Hadley, M S; Harling, J D; Herdon, H J; Orlek, B S; Riley, G J; Stead, R E; Stean, T O; Thompson, M; Upton, N; Ward, R W.

Affiliation

Chan WN; SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.

Bioorg Med Chem ; 8(8): 2085-94, 2000 Aug.

Article in En | MEDLINE | ID: mdl-11003154

Subject(s)

Anticonvulsants/chemistry; Anticonvulsants/pharmacology; Benzamides/chemistry; Benzamides/pharmacology; Drug Design; Isoquinolines/chemistry; Isoquinolines/pharmacology; Animals; Anticonvulsants/chemical synthesis; Anticonvulsants/metabolism; Benzamides/chemical synthesis; Benzamides/metabolism; Benzopyrans/metabolism; Binding Sites; Brain Chemistry; Drug Evaluation, Preclinical; Isoquinolines/chemical synthesis; Isoquinolines/metabolism; Male; Mice; Models, Molecular; Molecular Structure; Radioligand Assay; Rats; Seizures/drug therapy; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Drug Design / Isoquinolines / Anticonvulsants Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2000 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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