Enhanced pneumocystis carinii activity of new primaquine analogues.

Goodwin, T E; Boylan, C J; Current, W L; Byrd, J C; Edwards, C B; Fuller, D A; Green, J L; Larocca, C D; Raney, K D; Ross, A S; Tucker, W A

Goodwin, T E; Boylan, C J; Current, W L; Byrd, J C; Edwards, C B; Fuller, D A; Green, J L; Larocca, C D; Raney, K D; Ross, A S; Tucker, W A.

Affiliation

Goodwin TE; Department of Chemistry, Hendrix College, Conway, AR 72032, USA. goodwin@hendrix.edu

Bioorg Med Chem Lett ; 10(19): 2205-8, 2000 Oct 02.

Article in En | MEDLINE | ID: mdl-11012030

ABSTRACT

ABSTRACT

New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.

Subject(s)

Antifungal Agents/therapeutic use; Pneumocystis Infections/drug therapy; Primaquine/analogs & derivatives; Primaquine/therapeutic use; Animals; Antifungal Agents/chemical synthesis; Antifungal Agents/chemistry; Antifungal Agents/pharmacology; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Molecular Structure; Pneumocystis/drug effects; Primaquine/chemical synthesis; Primaquine/chemistry; Primaquine/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Primaquine / Pneumocystis Infections / Antifungal Agents Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2000 Document type: Article Affiliation country: United States

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