The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks.

Drici, M D; Diochot, S; Terrenoire, C; Romey, G; Lazdunski, M

Drici, M D; Diochot, S; Terrenoire, C; Romey, G; Lazdunski, M.

Affiliation

Drici MD; Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

Br J Pharmacol ; 131(3): 569-77, 2000 Oct.

Article in En | MEDLINE | ID: mdl-11015309

Subject(s)

Acetylcholine/pharmacology; Bee Venoms/pharmacology; Heart Block/chemically induced; Potassium Channels, Inwardly Rectifying; Potassium Channels/metabolism; Animals; Atrioventricular Node/drug effects; Atrioventricular Node/physiology; Drug Interactions; Electrocardiography/drug effects; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guinea Pigs; Heart/drug effects; Heart/physiology; Heart Block/physiopathology; Heart Conduction System/drug effects; Heart Conduction System/physiology; Heart Rate/drug effects; Oocytes; Potassium Channel Blockers; Rabbits; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bee Venoms / Potassium Channels / Acetylcholine / Potassium Channels, Inwardly Rectifying / Heart Block Limits: Animals Language: En Journal: Br J Pharmacol Year: 2000 Document type: Article Affiliation country: France Country of publication: United kingdom

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