Action of somatostatin analogue (octreotide) on experimental hepatic encephalopathy in rats.
Hepatogastroenterology
; 47(34): 1060-2, 2000.
Article
in En
| MEDLINE
| ID: mdl-11020879
BACKGROUND/AIMS: We investigated the effect of a somatostatin analogue (octreotide) on hepatic encephalopathy in a rat model. Fulminant hepatic failure was induced by thioacetamide twice daily for 3 consecutive days. METHODOLOGY: Animals with hepatic encephalopathy grade III were divided into 2 groups. The groups received saline (control) or octreotide. In both groups the distance traveled in the open field activity, neurological score and mortality time were evaluated before and after the treatment. RESULTS: In the control group the motor activity was 13.7 +/- 6.4 and 12.9 +/- 5.5 cm/10 min, the neurological score was 8.4 +/- 0.9 and 8.5 +/- 1.3 before and after the treatment, respectively. In the octreotide group the motor activity was 11.4 +/- 5.0 and 10.4 +/- 3.5 cm/10 min, the neurological score was 8.8 +/- 1.5 and 8.6 +/- 0.9 before and after the treatment, respectively. Mortality times in the saline and octreotide group were 76.1 +/- 28.1 and 89.7 +/- 46.5 min, respectively. All parameters of this study were statistically not significant. CONCLUSIONS: This study demonstrated that somatostatin analogue, octreotide does not effect hepatic encephalopathy in an experimental rat model.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Octreotide
/
Hepatic Encephalopathy
/
Hormones
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Hepatogastroenterology
Year:
2000
Document type:
Article
Affiliation country:
Turkey
Country of publication:
Greece