Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.
Ann Neurol
; 48(4): 679-84, 2000 Oct.
Article
in En
| MEDLINE
| ID: mdl-11026456
ABSTRACT
We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histocompatibility Antigens Class I
/
HLA Antigens
/
Muscles
/
Myositis
Limits:
Humans
Language:
En
Journal:
Ann Neurol
Year:
2000
Document type:
Article
Affiliation country:
Germany