The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells.

Hiltbold, E M; Vlad, A M; Ciborowski, P; Watkins, S C; Finn, O J

Hiltbold, E M; Vlad, A M; Ciborowski, P; Watkins, S C; Finn, O J.

Affiliation

Hiltbold EM; Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA.

J Immunol ; 165(7): 3730-41, 2000 Oct 01.

Article in En | MEDLINE | ID: mdl-11034378

Subject(s)

Antigen Presentation/immunology; Dendritic Cells/immunology; Dendritic Cells/metabolism; Immune Tolerance; Intracellular Fluid/immunology; Lectins, C-Type; Mannose-Binding Lectins; Mucin-1/immunology; Mucin-1/metabolism; Amino Acid Sequence; Antibodies, Blocking/pharmacology; Antigen Presentation/drug effects; Biological Transport/drug effects; Biological Transport/immunology; Cell Membrane/immunology; Cell Membrane/metabolism; Dendritic Cells/drug effects; Dendritic Cells/ultrastructure; Endosomes/immunology; Endosomes/metabolism; Glycosylation; Hemocyanins/immunology; Hemocyanins/metabolism; Humans; Intracellular Fluid/drug effects; Intracellular Fluid/metabolism; Mannans/pharmacology; Mannose/pharmacology; Mannose Receptor; Molecular Sequence Data; Mucin-1/blood; Mucin-1/ultrastructure; Protein Binding/drug effects; Protein Binding/immunology; Receptor, ErbB-2/immunology; Receptor, ErbB-2/metabolism; Receptors, Cell Surface/antagonists & inhibitors; Receptors, Cell Surface/immunology; Receptors, Cell Surface/physiology; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Antigen Presentation / Mucin-1 / Lectins, C-Type / Mannose-Binding Lectins / Immune Tolerance / Intracellular Fluid Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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