Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes.

Winer, S; Gunaratnam, L; Astsatourov, I; Cheung, R K; Kubiak, V; Karges, W; Hammond-McKibben, D; Gaedigk, R; Graziano, D; Trucco, M; Becker, D J; Dosch, H M

Winer, S; Gunaratnam, L; Astsatourov, I; Cheung, R K; Kubiak, V; Karges, W; Hammond-McKibben, D; Gaedigk, R; Graziano, D; Trucco, M; Becker, D J; Dosch, H M.

Affiliation

Winer S; Department of Immunology, University of Toronto, Ontario, Canada.

J Immunol ; 165(7): 4086-94, 2000 Oct 01.

Article in En | MEDLINE | ID: mdl-11034420

Subject(s)

Autoantigens/biosynthesis; Diabetes Mellitus, Type 1/immunology; Diabetes Mellitus, Type 1/therapy; Histocompatibility Antigens Class II/metabolism; Peptides/administration & dosage; Peptides/immunology; Prediabetic State/immunology; Prediabetic State/therapy; Adoptive Transfer/methods; Amino Acid Sequence; Animals; Autoantigens/administration & dosage; Autoantigens/immunology; Autoantigens/metabolism; Epitopes, T-Lymphocyte/administration & dosage; Epitopes, T-Lymphocyte/immunology; Female; Immune Tolerance; Injections, Intravenous; Mice; Mice, Inbred NOD; Mice, Knockout; Molecular Mimicry; Molecular Sequence Data; Peptide Fragments/administration & dosage; Peptide Fragments/immunology; Peptide Fragments/metabolism; Peptides/metabolism; Protein Binding/immunology; Serum Albumin, Bovine/administration & dosage; Serum Albumin, Bovine/immunology; Serum Albumin, Bovine/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Prediabetic State / Autoantigens / Histocompatibility Antigens Class II / Diabetes Mellitus, Type 1 Limits: Animals Language: En Journal: J Immunol Year: 2000 Document type: Article Affiliation country: Canada Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links