Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

Reshkin, S J; Bellizzi, A; Caldeira, S; Albarani, V; Malanchi, I; Poignee, M; Alunni-Fabbroni, M; Casavola, V; Tommasino, M

Reshkin, S J; Bellizzi, A; Caldeira, S; Albarani, V; Malanchi, I; Poignee, M; Alunni-Fabbroni, M; Casavola, V; Tommasino, M.

Affiliation

Reshkin SJ; Department of General and Environmental Physiology, University of Bari, Bari, Italy.

FASEB J ; 14(14): 2185-97, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11053239

Subject(s)

Amiloride/analogs & derivatives; Cell Transformation, Neoplastic; Sodium-Hydrogen Exchangers/physiology; 3T3 Cells; Amiloride/pharmacology; Animals; Binding Sites; Binding, Competitive; Cell Division/drug effects; Cell Line; Cell Transformation, Neoplastic/genetics; Cell Transformation, Viral/genetics; Culture Media, Serum-Free/pharmacology; Cyclin E/drug effects; Cyclin E/metabolism; Glycolysis; Humans; Hydrogen-Ion Concentration; Keratinocytes/cytology; Keratinocytes/virology; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental/pathology; Neoplasms, Experimental/prevention & control; Oncogene Proteins, Viral/genetics; Oncogene Proteins, Viral/physiology; Papillomavirus E7 Proteins; Phenotype; S Phase; Sodium-Hydrogen Exchangers/antagonists & inhibitors; Sodium-Hydrogen Exchangers/metabolism; Transplantation, Heterologous; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Sodium-Hydrogen Exchangers / Amiloride Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2000 Document type: Article Affiliation country: Italy Country of publication: United States

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