Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms.

Barton, C C; Ganey, P E; Roth, R A

Barton, C C; Ganey, P E; Roth, R A.

Affiliation

Barton CC; Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA.

Toxicol Sci ; 58(1): 208-15, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11053557

Subject(s)

Aflatoxin B1/toxicity; Chemical and Drug Induced Liver Injury/etiology; Lipopolysaccharides/toxicity; Liver/drug effects; Neutrophils/drug effects; 5'-Nucleotidase/blood; Aflatoxin B1/administration & dosage; Alanine Transaminase/blood; Alkaline Phosphatase/blood; Animals; Apoptosis/drug effects; Aspartate Aminotransferases/blood; Bile Ducts, Intrahepatic/drug effects; Bile Ducts, Intrahepatic/pathology; Cell Count; Chemical and Drug Induced Liver Injury/blood; Chemical and Drug Induced Liver Injury/pathology; Drug Synergism; Escherichia coli; Hyperplasia/chemically induced; Hyperplasia/pathology; In Situ Nick-End Labeling; Injections, Intraperitoneal; Kupffer Cells/drug effects; Kupffer Cells/metabolism; Kupffer Cells/pathology; Lipopolysaccharides/administration & dosage; Liver/metabolism; Liver/pathology; Male; Neutrophils/pathology; Neutrophils/physiology; Proliferating Cell Nuclear Antigen/metabolism; Rats; Rats, Sprague-Dawley; gamma-Glutamyltransferase/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Aflatoxin B1 / Chemical and Drug Induced Liver Injury / Liver / Neutrophils Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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