Oestrogen receptor expression in normal breast epithelium.
Eur J Cancer
; 36 Suppl 4: S27-8, 2000 Sep.
Article
in En
| MEDLINE
| ID: mdl-11056304
ABSTRACT
Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast
/
Receptors, Estrogen
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Eur J Cancer
Year:
2000
Document type:
Article
Affiliation country:
United States