IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.
J Biol Chem
; 276(2): 1660-4, 2001 Jan 12.
Article
in En
| MEDLINE
| ID: mdl-11058597
ABSTRACT
We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombinant Proteins
/
Receptors, Interleukin
/
Interleukin-17
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Biol Chem
Year:
2001
Document type:
Article
Affiliation country:
United States