Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy.

Cosgrove, D; Rodgers, K; Meehan, D; Miller, C; Bovard, K; Gilroy, A; Gardner, H; Kotelianski, V; Gotwals, P; Amatucci, A; Kalluri, R

Cosgrove, D; Rodgers, K; Meehan, D; Miller, C; Bovard, K; Gilroy, A; Gardner, H; Kotelianski, V; Gotwals, P; Amatucci, A; Kalluri, R.

Affiliation

Cosgrove D; Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA. cosgrove@boystown.org

Am J Pathol ; 157(5): 1649-59, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11073824

Subject(s)

Integrins/physiology; Kidney Glomerulus/physiopathology; Nephritis, Hereditary/drug therapy; Nephritis, Hereditary/etiology; Transforming Growth Factor beta/physiology; Animals; Basement Membrane/pathology; Disease Progression; Immunoglobulin Fc Fragments/genetics; Integrin alpha1beta1; Integrins/genetics; Kidney Glomerulus/pathology; Mice; Mice, Knockout/genetics; Microscopy, Electron; Microscopy, Electron, Scanning; Nephritis, Hereditary/pathology; Receptors, Transforming Growth Factor beta/genetics; Recombinant Fusion Proteins/therapeutic use; Transforming Growth Factor beta1

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Integrins / Transforming Growth Factor beta / Kidney Glomerulus / Nephritis, Hereditary Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google