Chronic-intermittent hypoxia induces immediate early gene expression in the midline thalamus and epithalamus.

Sica, A L; Greenberg, H E; Scharf, S M; Ruggiero, D A

Sica, A L; Greenberg, H E; Scharf, S M; Ruggiero, D A.

Affiliation

Sica AL; Department of Medicine, Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, New York, NY 11040, USA.

Brain Res ; 883(2): 224-8, 2000 Nov 17.

Article in En | MEDLINE | ID: mdl-11074051

ABSTRACT

ABSTRACT

Chronic-intermittent hypoxia (CIH) was postulated to activate thalamic regions that are synaptically related to autonomic-related areas of the cerebral cortex. Animals exposed to CIH for 30 days exhibited c-fos labeling in paraventricular thalamic and lateral habenular nuclei. Our findings strongly suggest activation of a diencephalic network that participates in behavioral responses to chronic stress.

Subject(s)

Epithalamus/metabolism; Genes, Immediate-Early/physiology; Hypoxia, Brain/metabolism; Proto-Oncogene Proteins c-fos/metabolism; Thalamus/metabolism; Animals; Hypoxia, Brain/genetics; Male; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Thalamus / Hypoxia, Brain / Proto-Oncogene Proteins c-fos / Genes, Immediate-Early / Epithalamus Limits: Animals Language: En Journal: Brain Res Year: 2000 Document type: Article Affiliation country: United States Publication country: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS

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