Diheteropeptin, a novel substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. II. Physico-chemical properties and structure elucidation.

Masuoka, Y; Shin-Ya, K; Furihata, K; Matsumoto, H; Takebayashi, Y; Nagai, K; Suzuki, K; Hayakawa, Y; Seto, H

Masuoka, Y; Shin-Ya, K; Furihata, K; Matsumoto, H; Takebayashi, Y; Nagai, K; Suzuki, K; Hayakawa, Y; Seto, H.

Affiliation

Masuoka Y; Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.

J Antibiot (Tokyo) ; 53(8): 793-8, 2000 Aug.

Article in En | MEDLINE | ID: mdl-11079801

ABSTRACT

ABSTRACT

The structure of diheteropeptin (1), a TGF-beta-like active substance from Diheterospora chlamydosporia Q58044, was determined to be a new cyclotetrapeptide, cyclo[2aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S,8R,9R)-2-am ino-8,9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies.

Subject(s)

Decanoic Acids/chemistry; Circular Dichroism; Decanoic Acids/metabolism; Decanoic Acids/pharmacology; Hypocreales/metabolism; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Transforming Growth Factor beta/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Decanoic Acids Language: En Journal: J Antibiot (Tokyo) Year: 2000 Document type: Article Affiliation country: Japan

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