Are antioxidant levels measured immediately postoperatively an indicator of magnitude of injury?
Am J Surg
; 180(3): 212-6, 2000 Sep.
Article
in En
| MEDLINE
| ID: mdl-11084132
ABSTRACT
BACKGROUND:
Little is known about the changes that occur in antioxidant levels in response to surgical trauma. The antioxidant system may influence recovery and healing after operation. Miller et al described a reliable assay for total antioxidant capacity of serum. We studied changes in antioxidant levels secondary to operation using this assay.METHODS:
Twenty-seven patients were studied 14 abdominal and 13 breast cancer operations. Initial blood samples were obtained when starting the preoperative intravenous line, the second in the recovery room, and every 6 hours thereafter.RESULTS:
Levels did not correlate with diagnosis, extent of operation, age, body mass index, or complications. Differences between preoperative and postoperative values in the down and up groups were significant at P = 0.002 and P = 0.023, respectively. Differences in initial levels between the down and up groups were significant at P = 0.005. Levels 12 hours after operation were stable.CONCLUSIONS:
Rapid return to a baseline of approximately 1 micromole/L, regardless of the direction of initial response, supports the concept of a set point for regulation of serum's antioxidant capacity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Surgical Procedures, Operative
/
Breast Neoplasms
/
Abdomen
/
Antioxidants
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Am J Surg
Year:
2000
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA