Enzyme-mediated dialdehyde formation: an alternative pathway for benzo[a]pyrene 7,8-dihydrodiol bioactivation.

Stansbury, K H; Noll, D M; Groopman, J D; Trush, M A

Stansbury, K H; Noll, D M; Groopman, J D; Trush, M A.

Affiliation

Stansbury KH; Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.

Chem Res Toxicol ; 13(11): 1174-80, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11087440

Subject(s)

Aldehydes/pharmacokinetics; Carcinogens, Environmental/pharmacokinetics; Dihydroxydihydrobenzopyrenes/pharmacokinetics; Peroxidase/metabolism; Aldehydes/blood; Aldehydes/metabolism; Biotransformation; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes/blood; Heterocyclic Compounds/analysis; Heterocyclic Compounds/metabolism; Heterocyclic Compounds, 1-Ring; Humans; Hydrogen Peroxide/metabolism; Hydrogen Peroxide/pharmacology; Luminescent Measurements; Mass Spectrometry; Neutrophils/enzymology; Neutrophils/metabolism; Nuclear Magnetic Resonance, Biomolecular; Taurine/blood; Taurine/metabolism; Taurine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Dihydroxydihydrobenzopyrenes / Carcinogens, Environmental / Peroxidase / Aldehydes Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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