Pyridazine N-oxides. III. Synthesis and "in vitro" antimicrobial properties of N-oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo[f]cinnoline systems.
Arch Pharm (Weinheim)
; 333(10): 341-6, 2000 Oct.
Article
in En
| MEDLINE
| ID: mdl-11092137
ABSTRACT
A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a-c) and benzo[f]cinnoline N-oxides (4,5a-c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 micrograms/ml).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenanthrenes
/
Pyridazines
/
Anti-Bacterial Agents
Language:
En
Journal:
Arch Pharm (Weinheim)
Year:
2000
Document type:
Article
Affiliation country:
Italy