Very slow chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation.

Reist, M; Roy-de Vos, M; Montseny, J P; Mayer, J M; Carrupt, P A; Berger, Y; Testa, B

Reist, M; Roy-de Vos, M; Montseny, J P; Mayer, J M; Carrupt, P A; Berger, Y; Testa, B.

Affiliation

Reist M; Université de Lausanne, Institut de Chimie Thérapeutique, Ecole de Pharmacie, Lausanne, Switzerland.

Drug Metab Dispos ; 28(12): 1405-10, 2000 Dec.

Article in En | MEDLINE | ID: mdl-11095576

Subject(s)

Platelet Aggregation Inhibitors/pharmacokinetics; Ticlopidine/analogs & derivatives; Algorithms; Animals; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Hepatocytes/metabolism; Hydrolysis; In Vitro Techniques; Platelet Aggregation Inhibitors/metabolism; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Stereoisomerism; Ticlopidine/metabolism; Ticlopidine/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Ticlopidine / Platelet Aggregation Inhibitors Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2000 Document type: Article Affiliation country: Switzerland Country of publication: United States

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