Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate.

Hotze, E M; Wilson-Kubalek, E M; Rossjohn, J; Parker, M W; Johnson, A E; Tweten, R K

Hotze, E M; Wilson-Kubalek, E M; Rossjohn, J; Parker, M W; Johnson, A E; Tweten, R K.

Affiliation

Hotze EM; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA.

J Biol Chem ; 276(11): 8261-8, 2001 Mar 16.

Article in En | MEDLINE | ID: mdl-11102453

Subject(s)

Bacterial Toxins/chemistry; Cell Membrane/chemistry; Disulfides/chemistry; Protein Structure, Secondary; Dithiothreitol/pharmacology; Hemolysin Proteins; Hemolysis; Microscopy, Electron

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Cell Membrane / Protein Structure, Secondary / Disulfides Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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