JC virus genotypes in France: molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy.
J Infect Dis
; 183(2): 213-217, 2001 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-11110646
ABSTRACT
JC virus (JCV) induces progressive multifocal leukoencephalopathy (PML), especially in human immunodeficiency virus (HIV)-infected patients. Although JCV genotypes have primarily been associated with geographic patterns, a distinctive neuropathogenicity was recently attributed to genotype 2. A multicenter study was conducted to describe the distribution of JCV genotypes in France and to investigate correlations between genotypes and PML. Genotypes were determined by sequencing 494 bp in the VP1 capsid gene. Peripheral JCV was studied in 65 urine samples from 43 HIV-infected patients and from 22 control subjects. Genotypes 1, 4, 2, and 3 were detected in 52.3%, 30.8%, 12.3%, and 4.6% of the samples, respectively. In 56 brain or cerebrospinal fluid samples, PML-associated JCV of genotypes 1, 2, 4, and 3 was found in 66%, 19.7%, 8.9%, and 5.4%, respectively. Infection with JCV genotypes 1 or 2 was correlated with PML (odds ratio, 3.29). On the other hand, infection with JCV genotype 4 could represent a lower risk for PML.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukoencephalopathy, Progressive Multifocal
/
JC Virus
/
Capsid Proteins
Type of study:
Clinical_trials
/
Screening_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Infect Dis
Year:
2001
Document type:
Article
Affiliation country:
France