Antimalarial activities of peptide antibiotics isolated from fungi.
Antimicrob Agents Chemother
; 45(1): 145-9, 2001 Jan.
Article
in En
| MEDLINE
| ID: mdl-11120957
ABSTRACT
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of infections caused by drug resistant parasites. Secondary metabolites from fungi are an attractive source of chemotherapeutic agents. This work reports the isolation and in vitro antiplasmodial activities of peptide antibiotics of fungal origin. The three peptide antibiotics used in this study were efrapeptins, zervamicins, and antiamoebin. The high-performance liquid chromatography-purified peptides were characterized by nuclear magnetic resonance and mass spectral analysis. All three fungal peptides kill P. falciparum in culture with 50% inhibitory concentrations in the micromolar range. A possible mode of action of these peptide antibiotics on P. falciparum is presented.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Plasmodium falciparum
/
Ascomycota
/
Anti-Bacterial Agents
/
Antimalarials
Limits:
Animals
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2001
Document type:
Article
Affiliation country:
India