The effect of hypertonicity on nasal mucociliary clearance.
Clin Otolaryngol Allied Sci
; 25(6): 558-60, 2000 Dec.
Article
in En
| MEDLINE
| ID: mdl-11122299
ABSTRACT
The effect of the tonicity of saline nasal douching solutions on mucociliary clearance was studied in order to ascertain whether hypertonicity conferred any advantage. Thirty-eight normal subjects were included in a randomised double-blind crossover trial. Saline douching solutions of 0.9%, 3% and 5% tonicity were used and mucociliary clearance was measured by the saccharin clearance time (SCT). The resultant SCT after administration of 5% saline was significantly reduced compared to both 0.9% (P = 0.005) and 3% saline (P = 0.04). There was no difference between 0.9% and 3% saline administration. Thus hypertonic saline solutions improve mucociliary clearance, although this was only observed with solutions of 5% tonicity. The effect is probably brought about by changes in mucus rheology.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saline Solution, Hypertonic
/
Nasal Obstruction
/
Mucociliary Clearance
/
Nasal Mucosa
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Otolaryngol Allied Sci
Year:
2000
Document type:
Article
Affiliation country:
United kingdom