Lipophilic calcium antagonists in antiatherosclerotic therapy.
Curr Atheroscler Rep
; 2(1): 76-81, 2000 Jan.
Article
in En
| MEDLINE
| ID: mdl-11122728
ABSTRACT
Two key events in atherosclerotic plaque formation are the deposition of lipids in cells of the vascular wall, and migration and proliferation of arterial smooth muscle cells from the tunica intima toward the media. It has been shown that various calcium-channel antagonists may delay plaque formation in animal models. Among these, the new and highly lipophilic calcium antagonists, such as lacidipine and lercanidipine, display the most promising antiatherosclerotic activities. This paper will review and discuss these beneficial effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arteriosclerosis
/
Dihydropyridines
/
Calcium Channel Blockers
Limits:
Humans
Language:
En
Journal:
Curr Atheroscler Rep
Journal subject:
ANGIOLOGIA
Year:
2000
Document type:
Article
Affiliation country:
Italy