Carrier Proteins/physiology; Cytokines/physiology; Interferon-gamma/metabolism; Lymphocyte Activation; Membrane Glycoproteins/physiology; Signal Transduction/immunology; Th1 Cells/metabolism; Animals; Carrier Proteins/biosynthesis; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Differentiation/genetics; Cell Differentiation/immunology; Cytokines/biosynthesis; Cytokines/genetics; Cytokines/metabolism; Enzyme Activation/genetics; Enzyme Activation/immunology; Enzyme Inhibitors/pharmacology; Humans; Interferon-gamma/antagonists & inhibitors; Lymphocyte Activation/genetics; Membrane Glycoproteins/biosynthesis; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Tumor Necrosis Factor/genetics; Receptors, Tumor Necrosis Factor/metabolism; Receptors, Tumor Necrosis Factor/physiology; Recombinant Fusion Proteins/immunology; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacology; Signal Transduction/genetics; Th1 Cells/cytology; Th1 Cells/immunology; Th2 Cells/cytology; Th2 Cells/metabolism; Up-Regulation/drug effects; Up-Regulation/genetics; Up-Regulation/immunology; p38 Mitogen-Activated Protein Kinases