Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development.

Kumanogoh, A; Wang, X; Lee, I; Watanabe, C; Kamanaka, M; Shi, W; Yoshida, K; Sato, T; Habu, S; Itoh, M; Sakaguchi, N; Sakaguchi, S; Kikutani, H

Kumanogoh, A; Wang, X; Lee, I; Watanabe, C; Kamanaka, M; Shi, W; Yoshida, K; Sato, T; Habu, S; Itoh, M; Sakaguchi, N; Sakaguchi, S; Kikutani, H.

Affiliation

Kumanogoh A; Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan.

J Immunol ; 166(1): 353-60, 2001 Jan 01.

Article in En | MEDLINE | ID: mdl-11123312

Subject(s)

Autoantigens/immunology; CD40 Antigens/physiology; CD40 Ligand/genetics; CD40 Ligand/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; Animals; Antigen-Presenting Cells/immunology; Antigen-Presenting Cells/pathology; Autoantibodies/biosynthesis; Autoantibodies/blood; Autoimmune Diseases/genetics; Autoimmune Diseases/immunology; Autoimmune Diseases/pathology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD4-Positive T-Lymphocytes/pathology; CD40 Antigens/genetics; CD40 Antigens/metabolism; Cell Differentiation/genetics; Cell Differentiation/immunology; Leukocyte Common Antigens/biosynthesis; Lymphocyte Count; Lymphopenia/genetics; Lymphopenia/immunology; Lymphopenia/pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Nude; Receptors, Interleukin-2/biosynthesis; T-Lymphocyte Subsets/pathology; T-Lymphocyte Subsets/transplantation

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantigens / T-Lymphocyte Subsets / CD40 Antigens / CD40 Ligand Limits: Animals Language: En Journal: J Immunol Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United States

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