Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

Nicoll-Griffith, D A; Yergey, J A; Trimble, L A; Silva, J M; Li, C; Chauret, N; Gauthier, J Y; Grimm, E; Léger, S; Roy, P; Thérien, M; Wang, Z; Prasit, P; Zamboni, R; Young, R N; Brideau, C; Chan, C C; Mancini, J; Riendeau, D

Nicoll-Griffith, D A; Yergey, J A; Trimble, L A; Silva, J M; Li, C; Chauret, N; Gauthier, J Y; Grimm, E; Léger, S; Roy, P; Thérien, M; Wang, Z; Prasit, P; Zamboni, R; Young, R N; Brideau, C; Chan, C C; Mancini, J; Riendeau, D.

Affiliation

Nicoll-Griffith DA; Merck Frosst Centre for Therapeutic Research, Pointe-Claire-Dorval, Québec, Canada. deborah_nicoll_griffith@merck.com

Bioorg Med Chem Lett ; 10(23): 2683-6, 2000 Dec 04.

Article in En | MEDLINE | ID: mdl-11128651

Subject(s)

Cyclooxygenase Inhibitors/chemical synthesis; Cyclooxygenase Inhibitors/pharmacology; Lactones/chemical synthesis; Lactones/pharmacology; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/chemistry; Drug Evaluation, Preclinical; Humans; Isoenzymes/blood; Lactones/chemistry; Membrane Proteins; Prostaglandin-Endoperoxide Synthases/blood; Rats; Sulfones

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclooxygenase Inhibitors / Lactones Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2000 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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