Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle.

Torres, L M; Gamberini, M T; Roque, N F; Lima-Landman, M T; Souccar, C; Lapa, A J

Torres, L M; Gamberini, M T; Roque, N F; Lima-Landman, M T; Souccar, C; Lapa, A J.

Affiliation

Torres LM; Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Pharmacology, SP, Brazil. luce.farm@infar.epm.br

Phytochemistry ; 55(6): 617-9, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11130673

ABSTRACT

ABSTRACT

A bioassay monitored fractionation of a chloroform extract from the aerial parts of Baccharis trimera yielded a mixture that blocked the Ca2+-induced contractions of KCl- depolarized rat portal vein preparations. Pharmacological tests of two pure compounds isolated from the mixture revealed the dilactonic clerodane diterpene as the active compound.

Subject(s)

Asteraceae/chemistry; Diterpenes/pharmacology; Muscle Relaxation/drug effects; Muscle, Smooth, Vascular/drug effects; Animals; Diterpenes/chemistry; Diterpenes/isolation & purification; Female; Muscle, Smooth, Vascular/physiology; Rats; Rats, Wistar

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Asteraceae / Diterpenes / Muscle Relaxation / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Phytochemistry Year: 2000 Document type: Article Affiliation country: Brazil Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

Search on Google

Add to My VHL

XML

PubMed Links